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Good news! 20 Research Applications Have Been Approved by National Natural Science Foundation of China in 2022

  The project supported by National Natural Science Foundation of China is important in the field of basic research. The number of projects undertaken reflects the scientific research strength of an institution.

     20 research applications of Guang 'anmen Hospital have been approved by National Natural Science Foundation of China in 2022, including 2 key projects, 7 general projects and 11 youth science fund projects. 2 key projects were approved at the same time, achieving a historic breakthrough in Guang'anmen Hospital in the past decade. A total of 12.09 million yuan will be appropriated for these researches, a record high in the past five years.

1. Study on the Characteristics of TCM Syndromes of Ventricular Remodeling after Acute Myocardial Infarction and Mechanism of Blood-activating and Stasis-resolving Method

2. Study on the immune mechanism of integrated traditional Chinese and Western medicine in the prevention and treatment of bone destruction in rheumatoid arthritis

3. Mechanism of Shugan Jianpi formula regulating the mental stress related breast cancer metastasis based on MDSCs-TAPs-TANs mediated cancer cell dormancy rhythm

4. Study on the mechanism of Bushen Zhuyun Recipe improving endometrial receptivity in the treatment of recurrent miscarriage

5. Mechanism of Guben Tongluo Recipe in the treatment of H. pylori infection-related atrophic gastritis based on CXCR2/p38/p53/p21 aging pathway

6. To Explore the Molecular Mechanism of Psoriasis Transforming to Yin Syndrome from Yang Syndrome Based on HLA-DRB1 Regulating K17-mediated Foxp3+Treg Cells Proliferation

7. Research on the molecular mechanism of alleviating insulin resistance with Gegen Qinlian decoction based on the regulation of intestinal macrophage polarization mediated by "HDAC3-JAK1/2-STAT1" pathway

8. Based on the inflammatory microenvironment, the mechanism of regulating macrophage polarization and fibroblast interaction by Qingrehuoxue formula was investigatedTo investigate the mechanism of Qipo Shengmai Granule's intervention on atrial electrical remodeling in age-related atrial fibrillation based on PGC-1α/ATF5/UPRmt-mediated mitochondrial protein homeostasis

9. To explore the effective mechanism of Shuangshen Granule in preventing lung metastasis at its early stage by reconstructing pre-metastasis niche based on the γδT cell mediated by intestinal commensal bacteria via SCFA/Rh1-MCT1-HADC pathway

10. Predicting the effect of acupuncture for post-stroke aphasia based on core and peripheral language network using MRI and machine learning

11. To Explore the Mechanism Underlying the Effect of Reinforcing Qi and Dredging Collaterals Therapy to Improve Podocyte Injury in Diabetic Kidney Disease Based on SIRT1/Lipid metabolism/Ferroptosis Pathway

12. Research on Effect of Yiqi Huoxue Decoction on Myocardial Endoplasmic Reticulum-Mitochondria Interaction and Ca2+ crosstalk in Rats with Heart Failure Based on MAM

13. The mechanism of Xiaomanqingre formula mediating autophagy by AMPK/mTOR signaling pathway to regulate islet beta cells

14. Study on the mechanism of Shuangshen granules regulating TRM cell depletion and remodeling the immune microenvironment of lung cancer through TAMs mediated TGFβ-TOX/SOX4 signaling pathway

15. To investigate the mechanism of Qipo Shengmai Granule's intervention on atrial electrical remodeling in age-related atrial fibrillation based on PGC-1α/ATF5/UPRmt-mediated mitochondrial protein homeostasis

16. Mechanism of YiQiQingReGao formula on repairing podocyte actin cytoskeleton damage from tubule epithelial cell SIRT1 mediated tubule-podocyte crosstalk through

17. The molecular mechanism of Valeriana officinalis Linn. var. latiofolia miq. in improving mitochondrial damage in atherosclerosis with blood stasis syndrome through regulating PGC-1α/Sirt3 pathway based on dynamic visualization system

18. Investigation into the Mechanism of Polyphyllin I Enhances the Sensitivity of PD-1 mAb in Breast Cancer Based on Nanotechnology

19. Study on regulating autophagy and NLRP3 inflammasome crosstalk and alleviating podocyte injury via reinforcing Qi and clearing heat and toxin method

20. The discussion on the therapeutic mechanism of Huan Shuai Recipe on Peritoneal dialysis-associated peritoneal fibrosis of chronic kidney disease based on the mechanism of insensitivity to hypoxia mediated by “Indoxyl Sulfate/HIF-1α pathway”

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